RPS6

Across TCGA pan-cancer cohorts, RPS6 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RPS6’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RPS6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPS6 is over-expressed in tumor, although a few such as BRCA and HNSC show the opposite, repressed pattern.

KIRC, COAD, and LIHC are the cancer types where RPS6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPS6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.604	<.001	11	view →
COAD	Female	II,III,IV	+1.191	<.001	9	view →
LIHC	All	II,III,IV	+0.949	<.001	9	view →
BRCA	Female	II,III,IV	−0.557	<.001	8	view →
KIRP	All	II,III,IV	+0.629	.003	6	view →
CHOL	Male	All	+2.228	<.001	5	view →
HNSC	Female	IV	−0.810	.013	4	view →
KICH	Female	All	−1.023	.001	3	view →
LUSC	All	III,IV	−0.998	.008	2	view →
UCEC	All	All	−0.407	.030	2	view →
PRAD	All	All	+0.253	.025	2	view →
READ	All	All	+0.696	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

RPS6–KIRC

Open the KIRC breakdown →