RPS11

Across TCGA patient cohorts, RPS11 mutation is significantly associated with the RNA expression of many other genes, with 159 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPS11-associated genes across cancer lineages are MIR4269, RNU6-1318P, and LINC02274. Each is linked with RPS11 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPS11-to-partner and partner-to-RPS11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4269 grouped by RPS11-low versus RPS11-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS11→partner) and Y-score (partner→RPS11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR4269 →	+0.807	+3.630	<.001	.004	3	2
UCEC	RNU6-1318P →	+0.511	+3.773	<.001	<.001	3	2
UCEC	LINC02274 →	+0.556	+3.660	<.001	.003	3	2
SKCM	MTND1P21 →	+0.099	+5.485	<.001	.001	3	1
SKCM	MIR1270 →	+0.486	+4.565	.008	<.001	3	1
SKCM	CYP4F62P →	+0.050	+6.139	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 159 associations by consensus.

MIR4269 by RPS11 expression — SKCM

Explore this box plot interactively →