RPRM

Across TCGA patient cohorts, RPRM mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPRM-associated genes across cancer lineages are FOXO3a_pS318_S321, MEK1, and Notch1. Each is linked with RPRM in more than 1 cancer types. Because this analysis shows association rather than direction, both RPRM-to-partner and partner-to-RPRM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by RPRM-low versus RPRM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPRM→partner) and Y-score (partner→RPRM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.168	-2.990	.020	.036	3	1
UCEC	MEK1 →	+0.614	+3.000	.003	.036	2	2
UCEC	Notch1 →	+0.200	+2.817	.013	.036	3	1
UCEC	Bax →	+0.284	+3.000	.041	.037	3	1
UCEC	C-Raf →	+0.232	+3.000	.005	.037	3	1
UCEC	TIGAR →	+0.215	+3.026	.014	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

FOXO3a_pS318_S321 by RPRM expression — UCEC

Explore this box plot interactively →