RPRM

Across TCGA pan-cancer cohorts, RPRM RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated RPRM data layer compared with 2 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher RPRM RNA is associated with better overall survival. In most high-consensus cancer types, elevated RPRM expression acts as an unfavorable survival marker, although some lineages such as MESO and CHOL show a favorable association.

MESO, CHOL, and LGG are the cancer types where RPRM RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	All	0.571	0.240	<.001	81	view →
CHOL	DFS	Median	All	0.661	0.188	<.001	64	view →
LGG	OS	Median	All	0.883	0.736	<.001	48	view →
LUSC	OS	Median	All	0.835	0.714	<.001	43	view →
PAAD	DFS	Median	All	0.433	0.280	.004	38	view →
LIHC	DFS	Quartile	III,IV	0.162	0.360	.016	26	view →
UCS	DFS	Tertile	II,III,IV	0.563	0.167	.011	24	view →
UVM	DFS	Tertile	All	0.361	1.000	.014	22	view →
THCA	DFS	Quartile	All	0.665	0.940	.016	15	view →
READ	OS	Tertile	IV	0.573	1.000	.008	13	view →
TGCT	DFS	Tertile	All	0.924	0.705	.012	12	view →
PCPG	OS	Median	All	1.000	0.937	.020	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

RPRM–MESO (OS)

Open the MESO breakdown →