RPRM

Across TCGA pan-cancer cohorts, RPRM RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of RPRM’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where RPRM RNA is repressed in tumor relative to normal tissue. In most cancer types RPRM is over-expressed in tumor, although a few such as KICH and STAD show the opposite, repressed pattern.

KICH, STAD, and KIRC are the cancer types where RPRM tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPRM RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−2.996	<.001	11	view →
STAD	All	III,IV	−2.286	<.001	10	view →
KIRC	Male	II,III,IV	−1.703	<.001	10	view →
KIRP	Male	All	−1.506	<.001	9	view →
THCA	Male	IV	−1.630	<.001	8	view →
UCEC	All	All	−3.586	<.001	6	view →
LIHC	Female	All	+0.092	.006	6	view →
BLCA	Male	IV	−2.970	<.001	5	view →
LUSC	Female	All	+2.105	<.001	5	view →
READ	All	All	−2.152	.006	4	view →
COAD	Male	II,III,IV	−1.152	.005	4	view →
ESCA	All	All	−1.982	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

RPRM–KICH

Open the KICH breakdown →