RPRM

Across TCGA cell cohorts, RPRM mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible RPRM-associated genes across cancer lineages are SKOR2 and PRAMEF4. Each is linked with RPRM in more than 1 cancer types. Because this analysis shows association rather than direction, both RPRM-to-partner and partner-to-RPRM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKOR2 grouped by RPRM-low versus RPRM-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPRM→partner) and Y-score (partner→RPRM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SKOR2 →	+0.023	+5.285	<.001	.003	3	1
STOMACH	PRAMEF4 →	+0.006	+5.285	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

SKOR2 by RPRM expression — STOMACH

Explore this box plot interactively →