RPP40

Across TCGA cell cohorts, RPP40 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible RPP40-associated genes across cancer lineages are OR52N2, OR56B1, and OR52N4. Each is linked with RPP40 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPP40-to-partner and partner-to-RPP40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52N2 grouped by RPP40-low versus RPP40-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPP40→partner) and Y-score (partner→RPP40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR52N2 →	+0.141	+4.044	<.001	.009	3	1
LUNG_SCLC	OR56B1 →	+0.085	+4.269	<.001	.005	3	1
LUNG_SCLC	OR52N4 →	+0.134	+4.269	<.001	.005	3	1
LUNG_SCLC	FAM9A →	+0.214	+4.044	.001	.009	3	1
LUNG_SCLC	KRTAP21-1 →	+0.045	+4.643	<.001	.004	3	1
LUNG_SCLC	POTEB →	+0.010	+4.643	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

OR52N2 by RPP40 expression — LUNG_SCLC

Explore this box plot interactively →