RPP40

Across TCGA pan-cancer cohorts, RPP40 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of RPP40’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RPP40 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPP40 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, LUSC, and LIHC are the cancer types where RPP40 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPP40 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.319	<.001	11	view →
LUSC	Female	II,III,IV	+1.775	<.001	9	view →
LIHC	Male	II,III,IV	+1.538	<.001	9	view →
LUAD	Male	II,III,IV	+1.427	<.001	9	view →
COAD	Female	II,III,IV	+1.335	<.001	9	view →
STAD	All	II,III,IV	+1.030	<.001	9	view →
BLCA	All	All	+0.952	<.001	9	view →
KIRP	All	II,III,IV	+0.724	<.001	9	view →
HNSC	Male	IV	+0.851	<.001	8	view →
KICH	Female	II,III,IV	−1.588	<.001	6	view →
UCEC	All	II,III,IV	+0.930	<.001	6	view →
BRCA	All	All	+0.502	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

RPP40–KIRC

Open the KIRC breakdown →