RPP30

Across TCGA patient cohorts, RPP30 mutation is significantly associated with the RNA expression of many other genes, with 349 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPP30-associated genes across cancer lineages are SPATA31D5P, SOCS2P1, and DEFB119. Each is linked with RPP30 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPP30-to-partner and partner-to-RPP30 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA31D5P grouped by RPP30-low versus RPP30-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPP30→partner) and Y-score (partner→RPP30) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SPATA31D5P →	+0.014	+3.211	<.001	.005	3	2
BRCA	SOCS2P1 →	+0.292	+5.175	<.001	.007	3	2
CESC	DEFB119 →	+0.318	+5.418	<.001	.005	3	2
SKCM	SPANXN3 →	+0.528	+3.126	<.001	.007	3	2
BRCA	WBP1LP8 →	+0.049	+8.057	<.001	.005	3	1
BRCA	AQP7P5 →	+0.039	+5.610	.006	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 349 associations by consensus.

SPATA31D5P by RPP30 expression — SKCM

Explore this box plot interactively →