RPP25

Across TCGA patient cohorts, RPP25 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPP25-associated genes across cancer lineages are SNURFL, RNU1-105P, and RNU1-82P. Each is linked with RPP25 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPP25-to-partner and partner-to-RPP25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNURFL grouped by RPP25-low versus RPP25-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPP25→partner) and Y-score (partner→RPP25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	SNURFL →	+0.137	+5.254	<.001	<.001	3	1
CESC	RNU1-105P →	+0.276	+6.000	<.001	<.001	3	1
CESC	RNU1-82P →	+0.133	+4.559	<.001	.006	3	1
CESC	RPL39P25 →	+0.345	+4.200	<.001	.004	3	1
CESC	IGHVII-28-1 →	+0.556	+4.559	<.001	.006	3	1
CESC	FBLIM1P2 →	+0.052	+3.760	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

SNURFL by RPP25 expression — CESC

Explore this box plot interactively →