RPP25

Across TCGA pan-cancer cohorts, RPP25 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RPP25’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where RPP25 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPP25 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

STAD, BLCA, and THCA are the cancer types where RPP25 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPP25 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	Male	II,III,IV	+2.108	<.001	9	view →
BLCA	All	All	+1.091	<.001	8	view →
THCA	Male	III,IV	−1.017	<.001	8	view →
LUSC	Female	All	+0.993	<.001	8	view →
HNSC	Male	All	+1.197	<.001	7	view →
COAD	Female	II,III,IV	+0.791	<.001	7	view →
BRCA	Female	All	+0.437	<.001	6	view →
LUAD	All	II,III,IV	+0.502	.003	5	view →
UCEC	All	IV	+3.479	.040	4	view →
KIRC	All	II,III,IV	−0.492	.001	4	view →
CHOL	Male	All	+2.351	<.001	3	view →
ESCA	All	II,III,IV	+1.940	.007	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RPP25–STAD

Open the STAD breakdown →