RPL36AP40

Across TCGA pan-cancer cohorts, RPL36AP40 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of RPL36AP40’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RPL36AP40 RNA is repressed in tumor relative to normal tissue. In most cancer types RPL36AP40 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and LUAD are the cancer types where RPL36AP40 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPL36AP40 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.415	<.001	11	view →
KICH	All	III,IV	−0.687	.002	8	view →
LUAD	Male	II,III,IV	+0.172	.004	6	view →
KIRP	Male	All	−0.611	<.001	4	view →
BRCA	All	All	−0.125	<.001	4	view →
LIHC	All	All	+0.113	.006	2	view →
HNSC	All	II,III,IV	+0.064	.033	2	view →
THCA	Male	III,IV	+0.140	.027	1	view →
LUSC	Female	All	−0.079	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

RPL36AP40–KIRC

Open the KIRC breakdown →