RPL23

Across TCGA patient cohorts, RPL23 mutation is significantly associated with the RNA expression of many other genes, with 86 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPL23-associated genes across cancer lineages are MDH1P2, SUMO2P12, and PSMD14P1. Each is linked with RPL23 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPL23-to-partner and partner-to-RPL23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MDH1P2 grouped by RPL23-low versus RPL23-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL23→partner) and Y-score (partner→RPL23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MDH1P2 →	+0.076	+5.497	<.001	.004	3	2
HNSC	SUMO2P12 →	+0.243	+5.303	<.001	.006	3	2
COAD	PSMD14P1 →	+0.321	+4.384	<.001	.006	3	2
UCEC	LYPLA1P1 →	+0.085	+4.242	<.001	.006	3	2
UCEC	RPS29P32 →	+0.814	+3.277	<.001	.002	3	1
UCEC	CICP28 →	+0.027	+3.029	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 86 associations by consensus.

MDH1P2 by RPL23 expression — BLCA

Explore this box plot interactively →