RPL23

Across TCGA pan-cancer cohorts, RPL23 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of RPL23’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RPL23 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPL23 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

KIRC, KIRP, and LIHC are the cancer types where RPL23 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPL23 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.782	<.001	12	view →
KIRP	All	II,III,IV	+0.942	<.001	11	view →
LIHC	Female	II,III,IV	+1.120	<.001	9	view →
COAD	Female	II,III,IV	+0.624	<.001	8	view →
CHOL	Male	All	+2.284	<.001	5	view →
KICH	Female	All	−1.310	<.001	5	view →
UCEC	All	All	−0.533	.003	4	view →
BRCA	Female	II,III,IV	−0.422	<.001	4	view →
HNSC	Male	All	+0.302	.018	4	view →
PRAD	All	All	+0.316	<.001	2	view →
THCA	All	II,III,IV	+0.255	.026	2	view →
LUSC	All	All	+0.230	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

RPL23–KIRC

Open the KIRC breakdown →