RPL18A

Across TCGA patient cohorts, RPL18A mutation is significantly associated with the RNA expression of many other genes, with 2,768 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPL18A-associated genes across cancer lineages are SNORA35, RNA5SP26, and RNA5SP461. Each is linked with RPL18A in more than 2 cancer types. Because this analysis shows association rather than direction, both RPL18A-to-partner and partner-to-RPL18A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORA35 grouped by RPL18A-low versus RPL18A-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL18A→partner) and Y-score (partner→RPL18A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	SNORA35 →	+0.268	+7.640	<.001	.009	3	3
BRCA	RNA5SP26 →	+0.237	+8.055	<.001	.007	3	2
BRCA	RNA5SP461 →	+0.267	+8.471	<.001	.005	3	2
BRCA	DUXAP11 →	+0.059	+7.731	<.001	.009	3	2
UCEC	MIR1266 →	+0.220	+3.286	<.001	<.001	3	2
SKCM	RNU6-660P →	+0.408	+4.884	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,768 associations by consensus.

SNORA35 by RPL18A expression — BLCA

Explore this box plot interactively →