RPL18A

Across TCGA pan-cancer cohorts, RPL18A RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RPL18A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RPL18A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPL18A is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KIRC, COAD, and LIHC are the cancer types where RPL18A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPL18A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.209	<.001	12	view →
COAD	Female	II,III,IV	+1.184	<.001	11	view →
LIHC	Female	II,III,IV	+1.187	<.001	9	view →
KIRP	All	III,IV	+0.970	<.001	8	view →
CHOL	Male	All	+2.361	<.001	5	view →
LUSC	Male	All	+0.496	<.001	4	view →
KICH	Female	All	−0.749	.010	2	view →
READ	All	All	+0.721	.009	2	view →
PRAD	All	All	+0.334	.004	2	view →
STAD	All	IV	+0.953	.049	1	view →
ESCA	All	All	+0.923	.017	1	view →
THCA	All	All	−0.222	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RPL18A–KIRC

Open the KIRC breakdown →