RPH3AL

Across TCGA patient cohorts, RPH3AL mutation is significantly associated with the RNA expression of many other genes, with 1,678 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPH3AL-associated genes across cancer lineages are C12orf43, ZFYVE19, and HEXIM2. Each is linked with RPH3AL in more than 1 cancer types. Because this analysis shows association rather than direction, both RPH3AL-to-partner and partner-to-RPH3AL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C12orf43 grouped by RPH3AL-low versus RPH3AL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPH3AL→partner) and Y-score (partner→RPH3AL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C12orf43 →	+0.340	+4.098	.001	<.001	3	2
UCEC	ZFYVE19 →	+0.430	+3.346	.002	.005	3	2
UCEC	HEXIM2 →	+0.497	+2.353	<.001	.003	3	2
UCEC	ELP5 →	+0.388	+2.354	.006	.003	3	2
UCEC	COPRS →	+0.480	+3.617	.002	.001	3	2
SKCM	TSR2 →	+0.366	+2.616	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,678 associations by consensus.

C12orf43 by RPH3AL expression — UCEC

Explore this box plot interactively →