RPH3AL

Across TCGA pan-cancer cohorts, RPH3AL RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated RPH3AL data layer compared with 6 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher RPH3AL RNA is associated with better overall survival. In most high-consensus cancer types, elevated RPH3AL expression acts as an unfavorable survival marker, although some lineages such as BLCA and MESO show a favorable association.

BLCA, UVM, and LUSC are the cancer types where RPH3AL RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Quartile	IV	0.697	0.368	<.001	70	view →
UVM	DFS	Tertile	All	0.444	0.808	<.001	68	view →
LUSC	DFS	Median	All	0.707	0.806	.002	64	view →
MESO	OS	Median	II,III,IV	0.683	0.423	.003	57	view →
KIRC	OS	Median	All	0.728	0.539	<.001	45	view →
HNSC	DFS	Tertile	IV	0.700	0.525	.004	40	view →
THCA	OS	Tertile	II,III,IV	0.677	1.000	.006	23	view →
ACC	OS	Tertile	II,III,IV	0.787	0.962	.014	19	view →
TGCT	DFS	Tertile	All	0.680	0.938	.001	18	view →
BRCA	OS	Tertile	III,IV	0.944	0.832	.003	15	view →
LUAD	DFS	Tertile	II,III,IV	0.568	0.771	.011	12	view →
ESCA	DFS	Tertile	All	0.325	1.000	.007	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

RPH3AL–BLCA (OS)

Open the BLCA breakdown →