RPH3AL

Across TCGA pan-cancer cohorts, RPH3AL RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RPH3AL’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where RPH3AL RNA is repressed in tumor relative to normal tissue. In most cancer types RPH3AL is over-expressed in tumor, although a few such as KICH and HNSC show the opposite, repressed pattern.

KICH, HNSC, and LUSC are the cancer types where RPH3AL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPH3AL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−1.199	<.001	9	view →
HNSC	All	II,III,IV	−0.760	<.001	9	view →
LUSC	Male	II,III,IV	−1.896	<.001	7	view →
BRCA	Female	All	−0.611	<.001	6	view →
KIRC	All	II,III,IV	−0.430	<.001	6	view →
STAD	Male	All	+0.648	.004	4	view →
LUAD	All	All	−0.430	.001	4	view →
CHOL	All	All	+0.623	.004	2	view →
UCEC	All	All	−0.602	.012	2	view →
LIHC	Male	II,III,IV	−0.430	.044	2	view →
KIRP	Male	All	−0.488	.042	1	view →
COAD	Male	IV	+0.472	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

RPH3AL–KICH

Open the KICH breakdown →