RPH3AL

Across TCGA cell cohorts, RPH3AL mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RPH3AL-associated genes across cancer lineages are PPP1R2C, OR10W1, and ACSM6. Each is linked with RPH3AL in more than 1 cancer types. Because this analysis shows association rather than direction, both RPH3AL-to-partner and partner-to-RPH3AL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP1R2C grouped by RPH3AL-low versus RPH3AL-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPH3AL→partner) and Y-score (partner→RPH3AL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPP1R2C →	+0.028	+2.925	.002	.007	3	1
LARGE_INTESTINE	OR10W1 →	+0.010	+3.562	<.001	.002	3	1
LARGE_INTESTINE	ACSM6 →	+0.024	+3.584	<.001	.002	3	1
CNS	OR11H6 →	+0.035	+5.321	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

PPP1R2C by RPH3AL expression — LARGE_INTESTINE

Explore this box plot interactively →