RPGRIP1L

Across TCGA patient cohorts, RPGRIP1L mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPGRIP1L-associated genes across cancer lineages are PCNA, Cyclin-B1, and INPP4B. Each is linked with RPGRIP1L in more than 1 cancer types. Because this analysis shows association rather than direction, both RPGRIP1L-to-partner and partner-to-RPGRIP1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by RPGRIP1L-low versus RPGRIP1L-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPGRIP1L→partner) and Y-score (partner→RPGRIP1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	PCNA →	+0.191	+3.169	.039	.018	3	2
BLCA	Cyclin-B1 →	+0.773	+3.000	<.001	.034	3	2
UCEC	INPP4B →	-0.183	-1.678	.040	.019	3	2
UCEC	ATM →	-0.382	-1.540	.002	.001	3	2
UCEC	4E-BP1 →	+0.161	+1.700	.031	.040	3	2
BLCA	FoxM1 →	+0.210	+2.321	.049	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

PCNA by RPGRIP1L expression — BLCA

Explore this box plot interactively →