RPGRIP1L

Across TCGA pan-cancer cohorts, RPGRIP1L RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of RPGRIP1L’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where RPGRIP1L RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPGRIP1L is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

COAD, KIRP, and KIRC are the cancer types where RPGRIP1L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPGRIP1L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	+0.958	<.001	12	view →
KIRP	All	IV	+1.492	<.001	11	view →
KIRC	Female	III,IV	+0.802	<.001	11	view →
LUAD	Male	All	+0.734	<.001	11	view →
LIHC	All	II,III,IV	+0.330	<.001	9	view →
BLCA	All	All	+0.618	<.001	8	view →
HNSC	Male	III,IV	+0.570	<.001	8	view →
THCA	All	II,III,IV	−0.366	<.001	8	view →
KICH	Female	II,III,IV	−1.032	<.001	7	view →
BRCA	All	III,IV	+0.599	<.001	6	view →
CHOL	All	II,III,IV	+1.849	<.001	5	view →
STAD	All	II,III,IV	+0.540	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

RPGRIP1L–COAD

Open the COAD breakdown →