RPGRIP1L

Across TCGA pan-cancer cohorts, RPGRIP1L RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated RPGRIP1L data layer compared with 6 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher RPGRIP1L RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RPGRIP1L expression acts as an unfavorable survival marker, although some lineages such as UCS and READ show a favorable association.

BLCA, STAD, and LIHC are the cancer types where RPGRIP1L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	All	0.248	0.708	<.001	63	view →
STAD	DFS	Median	All	0.312	0.628	.003	54	view →
LIHC	DFS	Median	All	0.354	0.507	<.001	47	view →
LGG	OS	Tertile	All	0.710	0.870	<.001	43	view →
THCA	DFS	Median	IV	0.483	0.901	.007	42	view →
UCS	DFS	Tertile	IV	0.936	0.488	.024	30	view →
MESO	DFS	Tertile	III,IV	0.296	0.559	.007	30	view →
READ	OS	Tertile	II,III,IV	0.946	0.393	.010	28	view →
BRCA	OS	Quartile	II,III,IV	0.573	0.741	.003	24	view →
HNSC	OS	Tertile	All	0.582	0.795	.008	21	view →
ACC	DFS	Quartile	All	0.521	0.915	.001	16	view →
THYM	DFS	Median	II,III,IV	0.945	0.515	.004	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

RPGRIP1L–BLCA (OS)

Open the BLCA breakdown →