RPGRIP1L

Across TCGA cell cohorts, RPGRIP1L mutation is significantly associated with the RNA expression of many other genes, with 169 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RPGRIP1L-associated genes across cancer lineages are OR10D3, LARP1B, and ZDHHC15. Each is linked with RPGRIP1L in more than 1 cancer types. Because this analysis shows association rather than direction, both RPGRIP1L-to-partner and partner-to-RPGRIP1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10D3 grouped by RPGRIP1L-low versus RPGRIP1L-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPGRIP1L→partner) and Y-score (partner→RPGRIP1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR10D3 →	+0.016	+4.321	.002	.009	3	2
LARGE_INTESTINE	LARP1B →	+0.691	+3.169	.003	.009	3	2
URINARY_TRACT	ZDHHC15 →	+0.398	+3.523	.005	.009	3	1
URINARY_TRACT	NKAIN3 →	+0.197	+4.050	<.001	.002	3	1
URINARY_TRACT	C1QTNF9 →	+0.026	+3.584	.002	.009	3	1
URINARY_TRACT	NXF2B →	+0.731	+3.716	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 169 associations by consensus.

OR10D3 by RPGRIP1L expression — CNS

Explore this box plot interactively →