RPE65

Across TCGA cell cohorts, RPE65 mutation is significantly associated with the RNA expression of many other genes, with 177 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RPE65-associated genes across cancer lineages are DCD, RPL3, and TRPA1. Each is linked with RPE65 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPE65-to-partner and partner-to-RPE65 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCD grouped by RPE65-low versus RPE65-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPE65→partner) and Y-score (partner→RPE65) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DCD →	+0.068	+4.977	.001	.007	3	2
LARGE_INTESTINE	RPL3 →	+0.516	+3.212	.004	.006	3	1
LARGE_INTESTINE	TRPA1 →	+0.410	+3.362	.004	.006	3	1
LARGE_INTESTINE	GIT1 →	+0.670	+3.212	.003	.006	3	1
LARGE_INTESTINE	VEGFA →	+1.464	+3.212	<.001	.006	3	1
LARGE_INTESTINE	STXBP3 →	+0.477	+3.212	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 177 associations by consensus.

DCD by RPE65 expression — SKIN

Explore this box plot interactively →