RPE65

Across TCGA pan-cancer cohorts, RPE65 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RPE65’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RPE65 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPE65 is over-expressed in tumor, although a few such as BLCA and BRCA show the opposite, repressed pattern.

HNSC, KIRC, and BLCA are the cancer types where RPE65 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPE65 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	+1.535	<.001	12	view →
KIRC	Male	All	+0.143	<.001	10	view →
BLCA	All	All	−0.436	.016	7	view →
BRCA	All	III,IV	−0.648	<.001	6	view →
UCEC	All	All	−0.408	.002	6	view →
LUSC	All	All	+0.226	.001	4	view →
PRAD	All	All	−1.047	<.001	2	view →
PAAD	Male	All	−0.110	.008	2	view →
KICH	Male	II,III,IV	+0.086	.008	2	view →
KIRP	All	IV	+0.060	.047	2	view →
LIHC	Male	All	+0.024	.002	2	view →
COAD	Male	All	−0.059	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

RPE65–HNSC

Open the HNSC breakdown →