RPA4

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RPA4 mutation is significantly associated with the RNA expression of many other genes, with 2,891 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPA4-associated genes across cancer lineages are RNU4-58P, RNU6-40P, and RNU6ATAC2P. Each is linked with RPA4 in more than 2 cancer types. Because this analysis shows association rather than direction, both RPA4-to-partner and partner-to-RPA4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPA4→partner) and Y-score (partner→RPA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECRNU4-58P →+0.176+2.396<.001.00133
COADRNU6-40P →+0.581+5.122<.001.00432
COADRNU6ATAC2P →+1.328+4.790<.001.00632
UCECPGAP2 →+0.401+3.185.001<.00132
UCECALDOA →+0.420+1.736.006.00732
UCECBAG3 →+0.568+2.459<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 2,891 associations by consensus.

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