Across TCGA pan-cancer cohorts, RPA4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RPA4’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RPA4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPA4 is over-expressed in tumor.
KIRC, COAD, and HNSC are the cancer types where RPA4 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPA4 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.