RP1

Across TCGA patient cohorts, RP1 mutation is significantly associated with the RNA expression of many other genes, with 8,342 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RP1-associated genes across cancer lineages are PALM, RAD51AP1, and CC2D2A. Each is linked with RP1 in more than 5 cancer types. Because this analysis shows association rather than direction, both RP1-to-partner and partner-to-RP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PALM grouped by RP1-low versus RP1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RP1→partner) and Y-score (partner→RP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PALM →	-0.977	-2.687	.001	.005	3	6
STAD	RAD51AP1 →	+0.582	+2.502	.005	.001	3	5
STAD	CC2D2A →	-0.628	-2.485	<.001	.001	3	5
UCEC	ZNF367 →	+0.617	+1.552	<.001	<.001	3	5
BRCA	ZNF473 →	+0.437	+2.641	.001	.005	3	5
LUSC	NR2C2AP →	+0.307	+1.833	.006	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,342 associations by consensus.

PALM by RP1 expression — STAD

Explore this box plot interactively →