RP1

Across TCGA pan-cancer cohorts, RP1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of RP1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RP1 RNA is repressed in tumor relative to normal tissue. In most cancer types RP1 is over-expressed in tumor, although a few such as KIRC and LUSC show the opposite, repressed pattern.

KIRC, LUSC, and COAD are the cancer types where RP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	−0.289	<.001	11	view →
LUSC	Female	II,III,IV	−0.845	<.001	9	view →
COAD	All	All	+0.079	<.001	8	view →
THCA	All	All	+0.059	<.001	6	view →
LUAD	Female	II,III,IV	−0.624	.001	5	view →
KICH	All	All	−0.368	<.001	5	view →
BRCA	Female	All	+0.198	.003	4	view →
STAD	All	All	+0.098	.013	3	view →
READ	All	All	+0.141	.019	1	view →
HNSC	Male	All	+0.052	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

RP1–KIRC

Open the KIRC breakdown →