RP1

Across TCGA pan-cancer cohorts, RP1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated RP1 data layer compared with 12 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher RP1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RP1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and SKCM show a favorable association.

ACC, KIRC, and BRCA are the cancer types where RP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.567	0.881	<.001	131	view →
KIRC	DFS	Tertile	All	0.543	0.723	<.001	116	view →
BRCA	DFS	Quartile	III,IV	0.960	0.801	<.001	78	view →
CESC	DFS	Median	All	0.404	0.661	<.001	76	view →
BLCA	DFS	Tertile	IV	0.231	0.534	.002	70	view →
PAAD	OS	Tertile	All	0.311	0.589	<.001	53	view →
UVM	DFS	Tertile	All	0.300	0.849	<.001	45	view →
KIRP	DFS	Tertile	II,III,IV	0.467	0.808	.004	41	view →
HNSC	OS	Quartile	All	0.699	0.828	.006	28	view →
LGG	DFS	Tertile	All	0.261	0.561	.001	22	view →
SARC	DFS	Tertile	All	0.376	0.562	.001	19	view →
SKCM	OS	Tertile	III,IV	0.525	0.242	.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

RP1–ACC (OS)

Open the ACC breakdown →