RP1

Across TCGA patient cohorts, RP1 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RP1-associated genes across cancer lineages are PCNA, TFRC, and Bim. Each is linked with RP1 in more than 4 cancer types. Because this analysis shows association rather than direction, both RP1-to-partner and partner-to-RP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by RP1-low versus RP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RP1→partner) and Y-score (partner→RP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.203	+1.387	<.001	.001	3	5
STAD	TFRC →	+0.540	+2.415	.017	.003	3	4
COAD	Bim →	+0.259	+2.115	.003	.017	3	4
UCEC	Caspase-7-cleavedD198 →	+0.576	+2.392	<.001	<.001	3	4
COAD	c-Jun_pS73 →	-0.142	-2.205	.006	.001	3	4
UCEC	4E-BP1 →	+0.307	+1.710	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

PCNA by RP1 expression — UCEC

Explore this box plot interactively →