RP1

Across TCGA cell cohorts, RP1 mutation is significantly associated with the RNA expression of many other genes, with 1,395 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RP1-associated genes across cancer lineages are IER3IP1, MAGEC3, and CAPN7. Each is linked with RP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RP1-to-partner and partner-to-RP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IER3IP1 grouped by RP1-low versus RP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RP1→partner) and Y-score (partner→RP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IER3IP1 →	+0.585	+1.808	.001	.001	3	3
LUNG_SCLC	MAGEC3 →	+0.309	+3.343	.008	.005	3	3
LARGE_INTESTINE	CAPN7 →	+0.425	+1.562	.001	.007	3	3
OESOPHAGUS	SIX6 →	+0.006	+3.158	<.001	.001	3	2
LUNG_NSCLC_LUAD	RSPH6A →	+0.048	+2.877	.002	.002	3	2
LARGE_INTESTINE	XPO7 →	+0.560	+2.700	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,395 associations by consensus.

IER3IP1 by RP1 expression — LARGE_INTESTINE

Explore this box plot interactively →