RP1

Across TCGA cell cohorts, RP1 mutation is significantly associated with the mutation status of many other genes, with 5,777 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RP1-associated genes across cancer lineages are LAMA2, MUC17, and CDH23. Each is linked with RP1 in more than 6 cancer types. Because this analysis shows association rather than direction, both RP1-to-partner and partner-to-RP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LAMA2 grouped by RP1-low versus RP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RP1→partner) and Y-score (partner→RP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LAMA2 →	+2.321	+2.974	<.001	<.001	1	7
LARGE_INTESTINE	MUC17 →	+2.502	+2.371	<.001	<.001	1	6
BLOOD_Lymphoma	CDH23 →	+2.694	+2.530	.007	.007	1	6
SKIN	RLF →	+3.832	+1.669	.001	.001	1	6
LARGE_INTESTINE	NOTCH3 →	+2.087	+2.190	<.001	<.001	1	6
LARGE_INTESTINE	FAT3 →	+1.938	+4.603	<.001	<.001	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,777 associations by consensus.

LAMA2 by RP1 expression — LARGE_INTESTINE

Explore this box plot interactively →