RORA-AS2

Across TCGA pan-cancer cohorts, RORA-AS2 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated RORA-AS2 data layer.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher RORA-AS2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RORA-AS2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

DLBC, HNSC, and UVM are the cancer types where RORA-AS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	DFS	Tertile	IV	0.125	0.744	<.001	117	view →
HNSC	DFS	Tertile	III,IV	0.946	0.569	.005	87	view →
UVM	DFS	Tertile	All	0.320	0.768	.016	72	view →
THYM	OS	Tertile	III,IV	0.438	1.000	<.001	69	view →
LUSC	OS	Tertile	II,III,IV	0.152	0.561	.004	42	view →
BRCA	OS	Tertile	III,IV	0.700	0.464	.007	36	view →
ESCA	DFS	Tertile	III,IV	0.627	0.267	.038	32	view →
STAD	DFS	Quartile	All	0.188	0.411	.005	20	view →
MESO	DFS	Tertile	IV	0.079	0.414	.004	18	view →
THCA	DFS	Tertile	IV	0.719	0.910	.029	18	view →
LGG	DFS	Quartile	All	0.640	0.764	.002	16	view →
SKCM	DFS	Tertile	III,IV	0.320	0.517	.015	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

RORA-AS2–DLBC (DFS)

Open the DLBC breakdown →