RORA-AS2

Across TCGA pan-cancer cohorts, RORA-AS2 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RORA-AS2’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where RORA-AS2 RNA is repressed in tumor relative to normal tissue. In most cancer types RORA-AS2 is over-expressed in tumor, although a few such as THCA and LIHC show the opposite, repressed pattern.

THCA, LIHC, and LIHC are the cancer types where RORA-AS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RORA-AS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.060	.001	4	view →
LIHC	Male	All	+0.041	.017	1	view →
LIHC	Female	II,III,IV	−0.030	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 2 lineages.

RORA-AS2–THCA

Open the THCA breakdown →