ROPN1L

Across TCGA patient cohorts, ROPN1L mutation is significantly associated with the RNA expression of many other genes, with 408 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ROPN1L-associated genes across cancer lineages are MIR378B, RPSAP65, and LINC02084. Each is linked with ROPN1L in more than 1 cancer types. Because this analysis shows association rather than direction, both ROPN1L-to-partner and partner-to-ROPN1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR378B grouped by ROPN1L-low versus ROPN1L-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROPN1L→partner) and Y-score (partner→ROPN1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MIR378B →	+0.688	+4.584	<.001	.005	3	2
SKCM	RPSAP65 →	+0.190	+3.892	<.001	.004	3	2
UCEC	LINC02084 →	+0.705	+3.595	<.001	.001	3	1
UCEC	MIR6870 →	+0.407	+2.589	.001	.008	3	1
UCEC	CCL4 →	+1.431	+3.329	<.001	.005	3	1
UCEC	TRBV15 →	+0.407	+3.545	.007	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 408 associations by consensus.

MIR378B by ROPN1L expression — LUAD

Explore this box plot interactively →