Q-omics provides the consensus-scored MIR378B profile across patient tissues and cancer cell-line models. MIR378B expression is associated with patient survival in 9 of 34 cancer types, with the highest sampling consensus in COAD. Among the 18 cancer types available for tumor–normal comparison, MIR378B is differentially expressed in 4, with the highest sampling consensus in KICH. Additionally, MIR378B RNA expression shows 11,701 significant gene co-expression associations, with the highest sampling consensus in GBM. Together, these results highlight COAD, KICH, and GBM as cancer lineages where MIR378B shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MIR378B — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MIR378B survival associations across molecular data types. MIR378B RNA expression shows survival associations in the most cancer types (9). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MIR378B RNA expression–survival associations across cancer types. High MIR378B expression shows unfavorable associations in COAD, UCEC, CHOL, PRAD, LGG and PCPG. The COAD Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify COAD as the clearest survival context for MIR378B RNA expression.
This table summarizes MIR378B tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 4. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for MIR378B. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MIR378B shows higher tumor expression in KICH, KIRC, LIHC and KIRP. The KICH box plot shows higher MIR378B RNA expression in tumor versus normal tissue (log2 FC = +1.105, t-test p < 0.001).
This table shows molecular features associated with MIR378B in patient tissues and cancer cell lines. In patient samples, MIR378B shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set.
