ROPN1L

Across TCGA pan-cancer cohorts, ROPN1L RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ROPN1L data layer compared with 2 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher ROPN1L RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ROPN1L expression acts as an unfavorable survival marker, although some lineages such as BRCA and MESO show a favorable association.

BRCA, ACC, and UVM are the cancer types where ROPN1L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Tertile	III,IV	0.612	0.434	.001	97	view →
ACC	DFS	Median	All	0.273	0.647	<.001	78	view →
UVM	OS	Median	All	0.412	0.888	<.001	76	view →
LGG	DFS	Tertile	All	0.342	0.522	<.001	43	view →
BLCA	DFS	Quartile	IV	0.151	0.370	.006	31	view →
KICH	OS	Median	All	0.774	0.970	.016	28	view →
UCS	DFS	Median	All	0.388	0.646	.006	26	view →
LUSC	DFS	Tertile	II,III,IV	0.635	0.817	.001	26	view →
MESO	DFS	Tertile	III,IV	0.679	0.127	.006	21	view →
KIRC	DFS	Median	All	0.733	0.508	.004	19	view →
KIRP	DFS	Tertile	All	0.553	0.814	.007	15	view →
UCEC	OS	Median	All	0.951	0.901	.011	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ROPN1L–BRCA (DFS)

Open the BRCA breakdown →