ROPN1L

Across TCGA cell cohorts, ROPN1L mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible ROPN1L-associated genes across cancer lineages are OR4E2, IFNA2, and TECRL. Each is linked with ROPN1L in more than 1 cancer types. Because this analysis shows association rather than direction, both ROPN1L-to-partner and partner-to-ROPN1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4E2 grouped by ROPN1L-low versus ROPN1L-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROPN1L→partner) and Y-score (partner→ROPN1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR4E2 →	+0.015	+4.977	<.001	.007	3	1
LUNG_SCLC	IFNA2 →	+0.019	+5.029	<.001	.006	3	1
LARGE_INTESTINE	TECRL →	+0.026	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR4E2 by ROPN1L expression — SKIN

Explore this box plot interactively →