ROBO3

Across TCGA patient cohorts, ROBO3 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,586 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible ROBO3-associated proteins across cancer lineages are PPFIBP1, PPM1F, and MRPS7. Each is linked with ROBO3 in more than 5 cancer types. Because this analysis shows association rather than direction, both ROBO3-to-partner and partner-to-ROBO3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ROBO3 versus PPFIBP1 in OV, with a Pearson correlation of 0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ROBO3→partner) and Y-score (partner→ROBO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PPFIBP1 →	+0.374	+0.944	<.001	<.001	3	6
BRCA	PPM1F →	+0.305	+0.865	<.001	<.001	3	6
LSCC	MRPS7 →	-0.431	-0.686	<.001	<.001	3	6
OV	MRPS5 →	-0.387	-1.137	<.001	<.001	3	6
BRCA	EFEMP2 →	+0.579	+0.670	<.001	<.001	3	6
OV	DPYSL2 →	+0.585	+0.650	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,586 associations by consensus.

ROBO3 vs PPFIBP1 — OV

Explore this scatter interactively →