ROBO3

Across TCGA pan-cancer cohorts, ROBO3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ROBO3’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ROBO3 RNA is repressed in tumor relative to normal tissue. In most cancer types ROBO3 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, LUAD, and KICH are the cancer types where ROBO3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ROBO3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.349	<.001	11	view →
LUAD	Male	II,III,IV	−0.784	<.001	9	view →
KICH	Female	All	−1.727	<.001	8	view →
LIHC	All	II,III,IV	+0.673	<.001	8	view →
UCEC	All	II,III,IV	−2.333	<.001	6	view →
BRCA	All	II,III,IV	−1.652	<.001	6	view →
CHOL	All	All	+1.157	<.001	4	view →
READ	All	All	−0.662	.007	2	view →
LUSC	Female	All	−0.559	.007	2	view →
PRAD	All	All	−0.530	<.001	2	view →
PAAD	Male	All	−0.205	.007	2	view →
BLCA	All	IV	−0.651	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ROBO3–THCA

Open the THCA breakdown →