RNU7-45P

Across TCGA pan-cancer cohorts, RNU7-45P RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of RNU7-45P’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where RNU7-45P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU7-45P is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KICH, BRCA, and LUAD are the cancer types where RNU7-45P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU7-45P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−1.571	<.001	8	view →
BRCA	All	III,IV	−0.738	.006	6	view →
LUAD	Female	II,III,IV	−1.074	.002	5	view →
LUSC	All	All	−0.974	<.001	5	view →
KIRC	Male	All	+0.452	.002	4	view →
CHOL	Male	All	+1.731	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

RNU7-45P–KICH

Open the KICH breakdown →