RNA, U6 small nuclear 89, pseudogeneGenealiases: []
Q-omics provides the consensus-scored RNU6-89P profile across patient tissues and cancer cell-line models. RNU6-89P expression is associated with patient survival in 11 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, RNU6-89P is differentially expressed in 1, with the highest sampling consensus in BRCA. Additionally, RNU6-89P RNA expression shows 6,259 significant gene co-expression associations, with the highest sampling consensus in LUAD. Together, these results highlight HNSC, BRCA, and LUAD as cancer lineages where RNU6-89P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for RNU6-89P — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes RNU6-89P survival associations across molecular data types. RNU6-89P RNA expression shows survival associations in the most cancer types (11). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible RNU6-89P RNA expression–survival associations across cancer types. High RNU6-89P expression shows unfavorable associations in HNSC, ACC, LIHC, CESC and GBM, but favorable associations in ESCA. The HNSC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify HNSC as the clearest survival context for RNU6-89P RNA expression.
This table summarizes RNU6-89P tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 1. The strongest signals are observed in BRCA for RNA.
This table ranks reproducible tumor–normal expression differences for RNU6-89P. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. RNU6-89P shows higher tumor expression in BRCA. The BRCA box plot shows higher RNU6-89P RNA expression in tumor versus normal tissue (log2 FC = +0.110, t-test p = .029).
This table shows molecular features associated with RNU6-89P in patient tissues and cancer cell lines. In patient samples, RNU6-89P shows the broadest associations at the RNA and protein expression levels, with LUAD recurring as the lineage with the largest associated feature set.
