RNU6-583P

Across TCGA pan-cancer cohorts, RNU6-583P RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of RNU6-583P’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where RNU6-583P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU6-583P is over-expressed in tumor, although a few such as PAAD show the opposite, repressed pattern.

LUSC, UCEC, and BRCA are the cancer types where RNU6-583P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-583P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	III,IV	+1.530	<.001	6	view →
UCEC	All	All	+0.526	.001	6	view →
BRCA	All	II,III,IV	+0.416	<.001	6	view →
LUAD	All	All	+0.447	<.001	5	view →
BLCA	Male	All	+0.740	.007	4	view →
STAD	Male	All	+0.687	<.001	4	view →
HNSC	All	II,III,IV	+0.247	.011	4	view →
ESCA	All	II,III,IV	+1.655	<.001	2	view →
PAAD	Female	All	−1.045	.003	2	view →
COAD	All	II,III,IV	+0.294	.037	2	view →
LIHC	All	All	+0.077	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

RNU6-583P–LUSC

Open the LUSC breakdown →