RNU6-548P

Across TCGA pan-cancer cohorts, RNU6-548P RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated RNU6-548P data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher RNU6-548P RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RNU6-548P expression acts as an unfavorable survival marker, although some lineages such as BRCA and LGG show a favorable association.

ACC, BRCA, and UVM are the cancer types where RNU6-548P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	IV	0.127	0.559	<.001	99	view →
BRCA	OS	Median	All	0.612	0.536	<.001	80	view →
UVM	DFS	Tertile	III,IV	0.126	0.831	<.001	40	view →
PAAD	OS	Median	All	0.378	0.590	.001	33	view →
LUSC	DFS	Quartile	II,III,IV	0.553	0.967	.001	24	view →
LGG	OS	Median	All	0.934	0.852	<.001	23	view →
MESO	OS	Tertile	All	0.221	0.363	.018	21	view →
LIHC	DFS	Quartile	III,IV	0.196	0.376	.006	19	view →
OV	OS	Median	All	0.802	0.876	.011	18	view →
LAML	DFS	Median	All	0.713	0.435	.006	18	view →
HNSC	DFS	Median	IV	0.344	0.264	.009	18	view →
DLBC	OS	Median	All	1.000	0.741	.005	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

RNU6-548P–ACC (DFS)

Open the ACC breakdown →