RNA, U6 small nuclear 548, pseudogeneGenealiases: []
Q-omics provides the consensus-scored RNU6-548P profile across patient tissues and cancer cell-line models. RNU6-548P expression is associated with patient survival in 27 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, RNU6-548P is differentially expressed in 14, with the highest sampling consensus in HNSC. Additionally, RNU6-548P RNA expression shows 12,676 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight ACC, HNSC, and UVM as cancer lineages where RNU6-548P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for RNU6-548P — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes RNU6-548P survival associations across molecular data types. RNU6-548P RNA expression shows survival associations in the most cancer types (27). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible RNU6-548P RNA expression–survival associations across cancer types. High RNU6-548P expression shows unfavorable associations in ACC, UVM, PAAD and LUSC, but favorable associations in BRCA and LGG. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for RNU6-548P RNA expression.
This table summarizes RNU6-548P tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for RNU6-548P. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. RNU6-548P shows higher tumor expression in HNSC, STAD, BRCA, LUSC, LUAD and BLCA. The HNSC box plot shows higher RNU6-548P RNA expression in tumor versus normal tissue (log2 FC = +0.528, t-test p < 0.001).
This table shows molecular features associated with RNU6-548P in patient tissues and cancer cell lines. In patient samples, RNU6-548P shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
