RNU6-548P

Across TCGA pan-cancer cohorts, RNU6-548P RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of RNU6-548P’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RNU6-548P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU6-548P is over-expressed in tumor.

HNSC, STAD, and BRCA are the cancer types where RNU6-548P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-548P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.528	<.001	10	view →
STAD	All	II,III,IV	+0.632	<.001	6	view →
BRCA	All	All	+0.620	<.001	6	view →
LUSC	Male	II,III,IV	+0.953	<.001	5	view →
LUAD	All	All	+0.682	<.001	5	view →
BLCA	All	III,IV	+0.543	.007	4	view →
KIRP	All	All	+0.207	.012	3	view →
KIRC	Male	All	+0.206	.003	3	view →
CHOL	Female	All	+0.963	.003	2	view →
PAAD	Male	All	+0.840	.013	2	view →
PRAD	All	All	+0.516	<.001	2	view →
UCEC	All	II,III,IV	+0.407	.031	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

RNU6-548P–HNSC

Open the HNSC breakdown →