Across TCGA pan-cancer cohorts, RNU6-476P RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RNU6-476P’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where RNU6-476P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU6-476P is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

BRCA, KICH, and LIHC are the cancer types where RNU6-476P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-476P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	All	−0.342	<.001	4	view →
KICH	Female	III,IV	−0.673	.001	2	view →
LIHC	Female	II,III,IV	+0.369	.022	2	view →
HNSC	Male	All	+0.297	.032	2	view →
CHOL	All	All	+0.902	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: RNU6-476P RNA expression & survival · all RNU6-476P data types