Across TCGA pan-cancer cohorts, RNU4-1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated RNU4-1 data layer.
The strongest signal is observed in colon adenocarcinoma (COAD), where higher RNU4-1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated RNU4-1 expression acts as an unfavorable survival marker, although some lineages such as COAD and STAD show a favorable association.
COAD, KIRC, and STAD are the cancer types where RNU4-1 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.